Name: Methyl Combo - Methylated B12 & Folate Supplement | Nature's Sunshine
SKU: 21689
Price: 31.45 USD
Availability: InStock

Provides bioavailable forms of vitamin B12 (methylcobalamin) and folate (methyltetrahydrofolate) that bypass enzymatic conversion requirements.
Delivers 1,000 mcg of vitamin B12 and 1,333 mcg DFE of folate per VegCap for optimal nutritional support.
Supports the methionine synthesis cycle, which is essential for cellular function and neurotransmitter production.
Features pre-activated nutrients that are readily absorbed and utilized by the body without requiring enzymatic conversion.
Convenient vegetarian capsule format provides concentrated B-vitamin nutrition in an easy-to-swallow form.

About Nature’s Sunshine Methyl Combo

Your body requires specific forms of B vitamins to function optimally, but not all vitamin supplements provide nutrients in their most usable forms. Nature’s Sunshine Methyl Combo delivers vitamin B12 and folate in their pre-activated, bioavailable forms that your body can immediately recognize and utilize without requiring complex enzymatic conversions.

Traditional folic acid supplements must undergo four separate enzymatic conversions before becoming the biologically active form called methyltetrahydrofolate. Similarly, standard vitamin B12 requires three enzymatic conversions to become methylcobalamin, the form your body actually uses. However, some individuals lack the necessary enzymes to make these conversions efficiently, which can limit the effectiveness of conventional B-vitamin supplements.

The Science Behind Methylated Vitamins

Methyl Combo bypasses these conversion challenges by providing vitamins B12 and folate in their already-activated forms. Methylcobalamin and methyltetrahydrofolate can be immediately utilized by your body’s cellular processes, ensuring maximum bioavailability and effectiveness.

When these two influential vitamins are in their bioavailable state, they work together to support the methionine synthesis cycle. This important biochemical pathway creates methionine, an essential amino acid that plays crucial roles in cellular function, protein synthesis, enzyme activity, and neurotransmitter production. Without adequate methylation support, these vital processes may not function at their optimal levels.

Supporting Your Body’s Essential Functions

The methylated forms of B12 and folate in this supplement support numerous bodily functions that depend on proper methylation. These nutrients contribute to the formation of red blood cells, support nervous system health, and help your body metabolize carbohydrates, fats, and proteins effectively.

Each VegCap contains 1,000 mcg of vitamin B12 as methylcobalamin and 1,333 mcg DFE (Dietary Folate Equivalent) of folate as methyltetrahydrofolate calcium salt. This potent combination provides substantial amounts of these essential nutrients in forms that don’t require your body to perform additional conversion work.

Quality You Can Trust

Nature’s Sunshine has been committed to herbal excellence since 1972, maintaining strict quality standards throughout the manufacturing process. Methyl Combo is formulated using carefully selected ingredients and comes in vegetarian capsules that meet the needs of various dietary preferences.

The clean ingredient profile focuses on delivering the essential nutrients without unnecessary additives, making this supplement suitable for individuals who prefer straightforward, effective nutritional support. The convenient once-daily dosing makes it easy to incorporate into your daily wellness routine.

Recommended Usage

Take 1 VegCap daily with food or as directed by your healthcare practitioner. Consistent daily use provides the best support for your body’s methylation processes.

Supplement Facts
Serving Size: 1 VegCap
Servings Per Container: 60
Amount Per 1 VegCap	Amount	% Daily Value
Folate (methyltetrahydrofolate calcium salt)	1333 mcg DFE	333%
Vitamin B₁₂ (methylcobalamin)	1000 mcg	41667%
†Daily Value not established.
Other Ingredients: Cellulose, dicalcium phosphate, vegetable capsule (hypromellose, water), magnesium stearate, silicon dioxide.

Frequently Asked Questions

What makes methylated B vitamins different from regular B vitamins?

Methylated B vitamins are in their pre-activated forms that your body can use immediately. Regular folic acid requires four enzymatic conversions to become methyltetrahydrofolate, while standard B12 requires three conversions to become methylcobalamin. Some people lack the enzymes needed for these conversions, making methylated forms more bioavailable.

Who should consider taking Methyl Combo?

This supplement is ideal for individuals who want highly bioavailable B vitamins, those who may have difficulty converting standard forms of folate and B12, vegetarians who need B12 support, and anyone looking to support their body’s methylation processes and nervous system health.

Can I take this supplement if I'm already taking a multivitamin?

While Methyl Combo can generally be taken alongside other supplements, it provides high potencies of B12 and folate. Consult with your healthcare practitioner to determine the appropriate combination for your individual needs and to avoid excessive intake of these nutrients.

What is the methionine synthesis cycle and why is it important?

The methionine synthesis cycle is a biochemical pathway where methylated B12 and folate work together to create methionine, an essential amino acid. Methionine is crucial for cellular function, protein synthesis, enzyme activity, and neurotransmitter production, making this cycle vital for overall health.

How long should I take this supplement to notice benefits?

Individual responses vary, but consistent daily use is recommended for optimal support. Some people may notice improvements in energy levels within a few weeks, while others may take longer. The methylated forms are immediately bioavailable, so your body can utilize them right away without waiting for conversion processes.

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