Supports normal-range cholesterol levels when combined with a healthy diet and exercise.
Features plant sterols that compete with cholesterol absorption in the digestive system.
Contains policosanol, a sugar cane extract traditionally studied for circulatory support.
Includes resveratrol to help maintain LDL and triglyceride levels already in the normal range.
Vegan-friendly VegCaps made from plant-based materials, suitable for vegetarian lifestyles.

About Nature’s Sunshine Cholester-Reg II

Managing healthy cholesterol levels is one of the most important steps you can take for long-term cardiovascular wellness. Nature’s Sunshine Cholester-Reg II offers a scientifically formulated blend of plant-based compounds specifically chosen to support normal-range cholesterol levels as part of a comprehensive heart-healthy lifestyle approach.

Launched in 2001, this carefully crafted formula combines five key ingredients that work together to support your body’s natural cholesterol management processes. Each VegCap delivers a 462mg proprietary blend containing artichoke leaves, plant sterols, inositol nicotinate, Japanese knotweed root extract, and policosanol – ingredients that have been individually studied for their role in cardiovascular health. The vegetarian capsules are made from plant-based materials, making this supplement suitable for vegan and vegetarian lifestyles.

How Plant Sterols Support Heart Health

The foundation of Cholester-Reg II lies in its plant sterol content. These naturally occurring compounds have a structure remarkably similar to cholesterol, which allows them to compete with dietary cholesterol for absorption in your digestive system. When plant sterols are present, less cholesterol is absorbed into your bloodstream, and excess plant sterols are naturally eliminated from your body.

Research has shown that consuming adequate amounts of plant sterols can support healthy cholesterol levels. These compounds are found naturally in small amounts in many plant foods, but supplementation provides a more concentrated and convenient way to ensure adequate intake for cardiovascular support.

The Power of Traditional Ingredients

Artichoke leaves have been valued since ancient times, with Greeks and Romans incorporating them into their diets for health benefits. Modern research suggests that artichoke leaf compounds may support liver function and help maintain cholesterol levels already within the normal range. The artichoke leaves in Cholester-Reg II are ethically sourced from small European farms where they are hand-harvested and sun-dried to preserve their natural compounds.

Policosanol, derived from sugar cane wax, has been studied for decades since Cuban researchers first investigated its effects on the circulatory system. This compound appears to work similarly to other natural cholesterol-supporting substances and has been researched for its potential role in maintaining healthy lipid levels in adults.

Key Ingredients

Ingredient	Botanical Name	Traditional Use
Artichoke Leaves	Cynara scolymus	Liver support, cholesterol management
Phytosterols	Plant-derived compounds	Cholesterol absorption competition
Japanese Knotweed Root Extract	Polygonum cuspidatum	Source of resveratrol, antioxidant support
Inositol Nicotinate	Flush-free niacin form	Circulatory support, smooth muscle relaxation
Policosanol	Sugar cane wax extract	Lipid management support

Comprehensive Cardiovascular Support

The Japanese knotweed root extract in this formula provides a natural source of resveratrol, a compound first discovered in 1939 when researchers noticed that certain plant-eating animals had improved longevity. Resveratrol supports the maintenance of LDL cholesterol and triglyceride levels that are already within the normal range.

Inositol nicotinate, a flush-free form of niacin, rounds out this comprehensive formula by supporting smooth muscle relaxation and healthy microcirculation. This form of niacin provides the benefits associated with vitamin B3 without the uncomfortable flushing that can occur with other forms.

Recommended Usage

Take 1 VegCap with a meal three times daily. For best results, use consistently as part of a heart-healthy diet and regular exercise program. Always consult with your healthcare provider before starting any new supplement regimen, especially if you are currently taking cholesterol-lowering medications.

Supplement Facts
Serving Size: 1 VegCap
Servings Per Container: 90
Amount Per 1 VegCap	Amount	% Daily Value
Proprietary Blend Artichoke Leaves Phytosterols Inositol Nicotinate Japanese Knotweed Root Extract (standardized to resveratrol) Policosanol	462 mg †	**
† Daily Value not established.
Other Ingredients: Vegetable capsule (hypromellose, water), cellulose, vegetable magnesium stearate, vegetable stearic acid, silicon dioxide.

Frequently Asked Questions

How does Cholester-Reg II support healthy cholesterol levels?

Cholester-Reg II works through multiple mechanisms. Plant sterols compete with cholesterol for absorption in your digestive system, while policosanol supports the body’s natural lipid management processes. Artichoke leaves provide traditional liver support, and resveratrol helps maintain LDL and triglyceride levels already in the normal range.

Can I take this supplement with prescription cholesterol medications?

You should always consult with your healthcare professional before using Cholester-Reg II if you are currently taking any cholesterol-lowering medications. Your doctor can help determine if this supplement is appropriate for your individual situation and may want to monitor your cholesterol levels more frequently.

How long should I take Cholester-Reg II to see results?

Individual results may vary, but cardiovascular support supplements typically work best when taken consistently over time as part of a comprehensive heart-healthy lifestyle. Many people find that consistent daily use for several months, combined with proper diet and exercise, provides optimal support for their cardiovascular wellness goals.

What makes the plant sterols in this formula effective?

Plant sterols have a molecular structure very similar to cholesterol, which allows them to compete with dietary cholesterol for absorption in your intestines. When plant sterols are present, less cholesterol is absorbed into your bloodstream. What’s particularly beneficial is that excess plant sterols are not absorbed by your body but are naturally eliminated.

Why should I take this supplement with meals?

Taking Cholester-Reg II with meals enhances the effectiveness of the plant sterols, as they work by competing with dietary cholesterol for absorption. Meals also help with the absorption of fat-soluble compounds and can minimize any potential digestive sensitivity. The recommended dosage is one VegCap with each main meal for optimal results.

Why Shop with Us?

Over 500 Quality Nature's Sunshine Supplements Available
Outstanding customer service.
Enjoy free U.S. shipping on orders over $100—delivered quickly and reliably.
Shop with confidence using encrypted payment processing and trusted online security.
Trusted Quality Standards - Nature's Sunshine uses rigorous testing and premium ingredients to ensure every supplement meets the highest standards for purity and potency.

Satisfaction Guaranteed
We stand behind every Nature’s Sunshine product. If you’re not completely satisfied with your purchase, simply contact us to arrange a return—we’ll provide a full refund, no questions asked. Your wellness and satisfaction are our top priorities.

Who is Cholester-Reg II For?

Adults seeking natural support for healthy cholesterol levels
Individuals interested in plant-based cardiovascular wellness approaches
People looking to complement their heart-healthy diet and exercise routine
Those wanting comprehensive circulatory system support with traditional botanicals
Adults 20 years and older committed to long-term cardiovascular health