Name: SAM-e 400mg - Mood & Cellular Health Support | Nature's Sunshine
SKU: 1845
Price: 64.95 USD
Availability: InStock

Provides 400 mg of SAM-e (S-Adenosylmethionine) in enteric-coated tablets for optimal absorption.
Supports the body’s natural production of important brain compounds like neurotransmitters.
May help support mood balance and emotional well-being as part of a healthy lifestyle.
Enteric coating protects the active ingredient from stomach acid for better bioavailability.
Made from S-Adenosylmethionine Tosylate Disulfate, a stable form of this important compound.

About Nature’s Sunshine SAM-e

SAM-e (S-Adenosylmethionine) is a naturally occurring compound found in every living cell of your body. This remarkable molecule plays a vital role in over 40 different biochemical reactions, making it one of the most important compounds for maintaining optimal cellular function. Nature’s Sunshine SAM-e provides 400 mg of this essential compound in a convenient, once-daily tablet designed to support your body’s natural processes.

Your body produces SAM-e primarily in the liver from methionine, an amino acid found in protein-rich foods. However, various factors including age, diet, and lifestyle can affect your body’s natural production of this important compound. That’s where supplementation can play a valuable role in supporting your wellness routine.

The Science Behind SAM-e

SAM-e serves as the body’s primary methyl donor, meaning it provides methyl groups that are essential for numerous biological processes. It is necessary for manufacturing important brain compounds like neurotransmitters and phospholipids. It is also involved with the production of hormones (like serotonin and melatonin), proteins, and the powerful antioxidant glutathione.

Research has shown that abnormal levels of SAMe in the body have been reported in liver diseases and depression, which has prompted scientists to investigate its potential benefits. SAM-e is required in over 40 biochemical reactions, helping with a variety of functions, including mood regulation, cognitive function, general nerve conditions, and liver and heart health.

Advanced Enteric Coating Technology

Nature’s Sunshine SAM-e features specialized enteric coating technology that protects the active ingredient from being broken down by stomach acid. This coating ensures that the SAM-e reaches your small intestine intact, where it can be properly absorbed and utilized by your body. This advanced delivery system maximizes the bioavailability of each 400 mg dose, helping you get the most from your supplement.

The stable S-Adenosylmethionine Tosylate Disulfate form used in this formula has been carefully selected for its ability to maintain potency and effectiveness. Each tablet is designed to provide consistent, reliable support for your body’s natural SAM-e needs.

Quality You Can Trust

Nature’s Sunshine has been a trusted leader in natural health solutions since 1972, and our SAM-e supplement reflects decades of expertise in nutritional science. Each batch is manufactured following strict quality standards to ensure purity, potency, and consistency. The convenient tablet format makes it easy to incorporate SAM-e into your daily wellness routine.

Recommended Usage

Take 1 tablet once or twice daily on an empty stomach with 8 oz. water. For best results, take SAM-e with folic acid and vitamin B12.

CAUTION: If you are taking prescription antidepressants or have bipolar (manic) depression, consult your physician before or during the use of this product. Pregnant or lactating women should consult their health care provider prior to taking this supplement.

Supplement Facts
Serving Size: 2 Tablets
Servings Per Container: 15
Amount Per 2 Tablets	Amount	% Daily Value
SAM-e (from S-Adenosylmethionine Tosylate Disulfate)	400 mg †	**
† Daily Value not established.
Other Ingredients: S-Adenosyl-L-methionine disulfate p-toluensulfonate, Microcrystalline cellulose, Magnesium hydroxide, Stearic acid, Magnesium stearate, Colloidal silica anhydrous, Calcium Oxide. Coating: (Talc, Flake shellac dewaxed, Arginine base, Glycerol, Magnesium stearate, Colloidal silica anhydrous, Sodium alginate.)

Frequently Asked Questions

What is SAM-e and what role does it play in the body?

SAM-e (S-Adenosylmethionine) is a naturally occurring compound found in all living cells. It serves as the body’s primary methyl donor and is involved in over 40 biochemical reactions. SAM-e is essential for producing neurotransmitters, hormones like serotonin and melatonin, and the antioxidant glutathione. It’s primarily made in the liver and plays important roles in mood regulation, cognitive function, and cellular health.

Why does this product use enteric coating?

The enteric coating protects SAM-e from being broken down by stomach acid, ensuring it reaches the small intestine where it can be properly absorbed. This specialized coating technology maximizes bioavailability and helps ensure you get the full benefit of each 400 mg dose.

When should I take SAM-e and why on an empty stomach?

SAM-e should be taken on an empty stomach with water because food can interfere with its absorption. Taking it 1-2 hours before meals or 2 hours after eating ensures optimal absorption. It’s also recommended to take SAM-e earlier in the day as it may support energy levels.

Why is it recommended to take SAM-e with folic acid and vitamin B12?

Folic acid and vitamin B12 work together with SAM-e in important metabolic pathways in the body. These B vitamins help support the body’s natural production and utilization of SAM-e, making supplementation more effective when taken together.

Who should avoid taking SAM-e or consult a healthcare provider first?

People with bipolar disorder should avoid SAM-e unless under medical supervision, as it may trigger manic episodes. Those taking prescription antidepressants should consult their physician before use due to potential interactions. Pregnant or nursing women should also consult their healthcare provider before taking this supplement.

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Who is SAM-e For?

Adults seeking natural support for mood and emotional well-being
Individuals interested in supporting their body’s natural neurotransmitter production
People looking for liver health and detoxification support
Those wanting to supplement their body’s natural SAM-e production
Anyone interested in cellular health and methylation support